Watch Carefully (two)pentobarbital will decrease the level or effect of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Potent CYP3A4 inducers may perhaps reduce suvorexant efficacy; if amplified suvorexant dose necessary, will not exceed 20 mg/working daypentobarbital will reduce the level or impact of borte